Product ID:ANTIMYCIN A STREPTOMYCES SP, 1782
MSDS Date:12/07/1998
FSC:6550
NIIN:00N092475
Status Code:A
MSDS Number: CJSSR

Emergency Phone: 202-783-7616 (INTERNATL)

Info Phone: 800-854-3417; 619-450-5558

Cage: 29089

Telephone: 619-450-5558; 800-854-3417

Cage: 29089

ANTIMYCIN A

CAS: 1397-94-0

RTECS: CD0350000

LD50 LC50 Mixture:LD50:(ORAL,RAT) 28 MG/KG & TOX INFO.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:MAY BE HARMFUL OR FATAL BY INGESTION,
INHALATION OF ABSORPTION THROUGH SKIN.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:SKIN: WASH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15
MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND WASH BEFORE
WEARING. CONSULT MD. EYES: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR
AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
EYELIDS WITH FINGERS. CONSULT MD. INHALATION: REMOVE TO FRESH AIR
AND MONITOR BREATHING. IF BREATHING BECOMES DIFFICULT, GIVE OXYGEN
AND CONSULT MD. IF BREATHING STOPS, GIVE ARTIFICIAL RESPIRATION
AND CONSULT MD. INGESTION: WASH MOUTH OUT WITH WATER AND CONSULT
LOCAL POISON CENTER AND MD.

Extinguishing Media:DRY CHEMICAL POWDER, CAROBN DIOXIDE, ALCOHOL OR
POLYMER FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.

Spill Release Procedures:EVACUATE AREA. WEAR A NIOSH APPROVED
SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER
GLOVES. SWEEP UP AND PLACE IN A SUITABLE CONTAINER. AVOID RAISING
DUST. HOLD FOR APPROPRIATE DISP OSAL. WASH SPILL SITE AND VENTILATE
AREA AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
A +4C REFRIGERATOR. PROTECT FROM LIGHT. MATERIAL IS TOXIC. AVOID
CONTACT WITH MATERIAL. AVOID PROLONGED OR REPEATED EXPOSURE. DO NOT
BREATHE DUST. AVOID CONTACT WITH SKIN AND EYES. IN CASE OF
ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY.
Other Precautions:MATERIAL SHOULD ONLY BE HANDLED BY QUALIFIED,
EXPERIENCED PROFESSIONALS.

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES & FULL LENGTH
FACESHIELD .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
WEAR SUITABLE PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING MATERIAL.
Supplemental Safety and Health
MFR'S INFO: MFR'S FAX #: (619) 452-3552; MFR'S INFO ON INGS: MOLECULAR
WEIGHT: 548.6. MOLECULAR FORMULA: C*29H*40N*2O*9. -- PHYSICAL &
CHEMICAL PROPERTIES: SOLUBILITY: SOLUBLE IN CHLOROFORM AND ETHANO
L.

Melt/Freeze Pt:>149.C, 300.2F
M.P/F.P Text:149-150C
Solubility in Water:SEE SUPP DATA
Appearance and Odor:WHITE SOLID.

Stability Indicator/Materials to Avoid:YES
NOT APPLICABLE.
Stability Condition to Avoid:STABLE UNDER NORMAL HANDLING PROCEDURES.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE, CARBON DIOXIDE AND NITROGEN
OXIDES.

Waste Disposal Methods:COUNTRY, FEDERAL, STATE AND LOCAL REGULATIONS
ARE VARIED AND CHANGE FREQUENTLY. FOR THIS REASON, MFR RECOMMENDS
THAT YOU CONTACT YOUR LOCAL DEPARTMENT OF HEALTH SERVICES FOR
INFORMATION ON THE DISPOSA L OF THIS PRODUCT OR ARRANGE FOR
DISPOSAL BY A LICENSED DISPOSAL COMPANY.

Toxicological Information:TOX DATA & REFERENCES: LD50:(ORAL,RAT) 28
MG/KG 1966; LD50:(ORAL,MUS) 55 MG/KG 1966; LD50:(ORAL,RBT) 10 MG/KG
1966; LD50:(ORAL,GPG) 1800 UG/KG 1966. "ANTIMICROBIAL AGENTS &
CHEMOTHERAPY (1961-70)". -, 757. LD50:(IPR,RAT) 810 UG/KG CHANGES
IN LUNG, THORAX/RESPIRATION 1953. "CANCER RESEARCH". 13, 49.
LD50:(IVN,MUS) 893 UG/KG 1956. "JOURNAL OF ANTIBIOTICS, SERIES A".
9,63. GENETIC DATA & REFERENCES: LYM; MUS; DOSE: 1 MG/L DNA
INHIBITION 1981 & OTHER MUTATION TEST SYSTEMS 1981. "NEOPLASMA".
28, 423. REFER TO RTECS FOR A DEFINITION OF ABBREVIATIONS USED IN
TEXT & FOR ADDNL INFO. THIS REPORT CONTAIN S ONLY SELECTED INFO
FROM RTECS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:NO INFORMATION AVAILABLE.

Transport Information:UN NUMBER: UN2811. PROPER SHIPPING NAME: TOXIC
SOLID, ORGANIC, N.O.S. IATA CLASS: 6.1. IATA PACKING GROUP 1.

Federal Regulatory Information:REGULATORY INFORMATION: T+. RISK
PHRASES: R26/27/28: VERY TOXIC BY INHALATION, IN CONTACT WITH SKIN
AND IF SWALLOWED. SAFETY PHRASES: S22: DO NOT BREATHE DUST. S24/25:
AVOID CONTACT WITH SKIN AND EYES . S36/37/39: WEAR SUITABLE
PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION. S45:IN CASE OF
ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY.
State Regulatory Information: